Publications

1. Chargé SB, Brack AS, Hughes SM. Aging-related satellite cell differentiation defect occurs prematurely after Ski-induced muscle hypertrophy. Am J Physiol Cell Physiol. 2002 Oct; 283(4):C1228-41. PMID: 12225986. 

 

2. Ferguson RE, Sun YB, Mercier P, Brack AS, Sykes BD, Corrie JE, Trentham DR, Irving M. In situ orientations of protein domains: troponin C in skeletal muscle fibers. Mol Cell. 2003 Apr; 11(4):865-74. PMID: 12718873. 

 

3. Brack AS, Brandmeier BD, Ferguson RE, Criddle S, Dale RE, Irving M. Bifunctional rhodamine probes of Myosin regulatory light chain orientation in relaxed skeletal muscle fibers. Biophys J. 2004 Apr; 86(4):2329-41. PMID: 15041671; PMCID: PMC1304082

 

4. Brack AS, Bildsoe H, Hughes SM. Evidence that satellite cell decrement contributes to preferential decline in nuclear number from large fibres during murine age-related muscle atrophy. J Cell Sci. 2005 Oct 15; 118(Pt 20):4813-21. PMID: 16219688. 

 

5. Bruusgaard JC, Brack AS, Hughes SM, Gundersen K. Muscle hypertrophy induced by the Ski protein: cyto-architecture and ultrastructure. Acta Physiol Scand. 2005 Oct; 185(2):141-9. PMID: 16168008. 

 

6. Brack AS, Conboy MJ, Roy S, Lee M, Kuo CJ, Keller C, Rando TA. Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis. Science. 2007 Aug 10; 317(5839):807-10. PMID: 17690295. 

 

7.Brack AS, Conboy IM, Conboy MJ, Shen J, Rando TA. A temporal switch from notch to Wnt signaling in muscle stem cells is necessary for normal adult myogenesis. Cell Stem Cell. 2008 Jan 10; 2(1):50-9. PMID: 18371421.

 

8. Chargé SB, Brack AS, Bayol SA, Hughes SM. MyoD- and nerve-dependent maintenance of MyoD expression in mature muscle fibres acts through the DRR/PRR element. BMC Dev Biol. 2008; 8:5. PMID: 18215268; PMCID: PMC2259323.

 

9. Brack AS, Murphy-Seiler F, Hanifi J, Deka J, Eyckerman S, Keller C, Aguet M, Rando TA. BCL9 is an essential component of canonical Wnt signaling that mediates the differentiation of myogenic progenitors during muscle regeneration. Dev Biol. 2009 Nov 1; 335(1):93-105. PMID: 19699733; PMCID: PMC3259687. 

 

10. Shea KL, Xiang W, LaPorta VS, Licht JD, Keller C, Basson MA, Brack AS. Sprouty1 regulates reversible quiescence of a self-renewing adult muscle stem cell pool during regeneration. Cell Stem Cell. 2010 Feb 5; 6(2):117-29. PMID: 20144785; PMCID: PMC2846417. 

 

11. Warren L, Manos PD, Ahfeldt T, Loh YH, Li H, Lau F, Ebina W, Mandal PK, Smith ZD, Meissner A, Daley GQ, Brack AS, Collins JJ, Cowan C, Schlaeger TM, Rossi DJ. Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell. 2010 Nov 5; 7(5):618-30. PMID: 20888316; PMCID: PMC3656821.

 

12. Chakkalakal JV, Jones KM, Basson MA, Brack AS. The aged niche disrupts muscle stem cell quiescence. Nature. 2012 Oct 18; 490(7420):355-60. PMID: 23023126; PMCID: PMC3605795. 

 

13. Li Z, Gilbert JA, Zhang Y, Zhang M, Qiu Q, Ramanujan K, Shavlakadze T, Eash JK, Scaramozza A, Goddeeris MM, Kirsch DG, Campbell KP, Brack AS, Glass DJ. An HMGA2-IGF2BP2 axis regulates myoblast proliferation and myogenesis. Dev Cell. 2012 Dec 11; 23(6):1176-88. PMID: 23177649; PMCID: PMC3645921. 

 

14. Chakkalakal JV, Christensen J, Xiang W, Tierney MT, Boscolo FS, Sacco A, Brack AS. Early forming label-retaining muscle stem cells require p27kip1 for maintenance of the primitive state. Development. 2014 Apr; 141(8):1649-59. PMID: 24715455; PMCID: PMC3978835

 

15. Abraham J, Nuñez-Álvarez Y, Hettmer S, Carrió E, Chen HI, Nishijo K, Huang ET, Prajapati SI, Walker RL, Davis S, Rebeles J, Wiebush H, McCleish AT, Hampton ST, Bjornson CR, Brack AS, Wagers AJ, Rando TA, Capecchi MR, Marini FC, Ehler BR, Zarzabal LA, Goros MW, Michalek JE, Meltzer PS, Langenau DM, LeGallo RD, Mansoor A, Chen Y, Suelves M, Rubin BP, Keller C. Lineage of origin in rhabdomyosarcoma informs pharmacological response. Genes Dev. 2014 Jul 15; 28(14):1578-91. PMID: 25030697; PMCID: PMC4102765. 

 

16. Egerman MA, Cadena SM, Gilbert JA, Meyer A, Nelson HN, Swalley SE, Mallozzi C, Jacobi C, Jennings LL, Clay I, Laurent G, Ma S, Brachat S, Lach-Trifilieff E, Shavlakadze T, Trendelenburg AU, Brack AS, Glass DJ. GDF11 Increases with Age and Inhibits Skeletal Muscle Regeneration. Cell Metab. 2015 Jul 7; 22(1):164-74. PMID: 26001423. 

 

17.Kollu S, Abou-Khalil R, Shen C, Brack AS. The Spindle Assembly Checkpoint Safeguards Genomic Integrity of Skeletal Muscle Satellite Cells. Stem Cell Reports. 2015 Jun 9; 4(6):1061-74. PMID: 25960061.

 

18. Brack AS, Muñoz-Cánoves P. The ins and outs of muscle stem cell aging. Skelet Muscle. 2015; 6:1. PMID: 26783424. 

 

19. Eliazer S, Brack AS. Lost in Translation: Preserving Satellite Cell Function with Global Translational Control. Cell Stem Cell. 2016 Jan 7; 18(1):5-7. PMID: 26748748. 

20. Harper SC, Brack A, MacDonnell S, Franti M, Olwin BB, Bailey BA, Rudnicki MA, Houser SR. Is Growth Differentiation Factor 11 a Realistic Therapeutic for Aging-Dependent Muscle Defects? Circ Res. 2016 Apr 1; 118(7):1143-50. PPMID: 27034276 PMID: 27034276 PMCID: PMC4829942

 

 

 

Reviews, Chapters and Editorials

 

1. Brack AS, Rando TA. Intrinsic changes and extrinsic influences of myogenic stem cell function during aging. Stem Cell Rev. 2007; 3(3):226-37. PMID: 17917136.

 

2. Brack, A.S and Rando, T.A. (2008) Age-Dependent Changes in Skeletal Muscle Regeneration. Skeletal Muscle Repair and Regeneration. 359-374.

 

3. Brack A. Adult muscle stem cells avoid death and Paxes. Cell Stem Cell. 2009 Aug 7; 5(2):132-4. PMID: 19664985.

 

4. Abou-Khalil R, Brack AS. Muscle stem cells and reversible quiescence: the role of sprouty. Cell Cycle. 2010 Jul 1; 9(13):2575-80. PMID: 20581433. 

 

5. Brack AS, Rando TA. Tissue-specific stem cells: lessons from the skeletal muscle satellite cell. Cell Stem Cell. 2012 May 4; 10(5):504-14. PMID: 22560074; PMCID: PMC3348769.

 

6. Chakkalakal J, Brack A. Extrinsic Regulation of Satellite Cell Function and Muscle Regeneration Capacity during Aging. J Stem Cell Res Ther. 2012 Sep 26;Suppl 11:001. PMID: 24678443 PMCID: PMC3965255

 

7. Brack AS. Ageing of the heart reversed by youthful systemic factors! EMBO J. 2013 Aug 14; 32(16):2189-90. PMID: 23860129; PMCID: PMC3746199. 

 

8. Brack AS, Hochedlinger K. ISSCR 2013: Back to Bean Town. Stem Cell Reports. 2013 Dec 17; 1(6):479-85. PMID: 25847520.

 

9. Jung Y, Brack AS. Cellular mechanisms of somatic stem cell aging. Curr Top Dev Biol. 2014; 107:405-38. PMID: 24439814; PMCID: PMC3982593.

 

10. Brack AS. Pax7 is back. Skelet Muscle. 2014; 4(1):24. PMID: 25546147.